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Abstract
Neomycin is formulated into nanoparticles in order to increase the therapeutic efficacy, decrease the dose of drug and to decrease the topical dose related toxic effects. The present study was aimed at the preparation of zinc nanoparticles (ZN), chitosan nanoparticles (CN), zinc neomycin nanoparticles (ZNN) and zinc chitosan neomycin nanoparticles (ZCNN) in order to compare their antibacterial activity. Nanoparticles were prepared by subjecting the nano suspension containing the specified ingredients to stirring at 40oC for 4-5 h. The prepared nanoparticles were evaluated for particle size and surface morphology by Transmission Electron Microscopy (TEM), mean particle size and particle size distribution by DLS, percentage yield, loading efficiency, in vitro drug release by diffusion technique and agar cup plate method. TEM microphotographs and zeta sizer analysis revealed that the prepared nanoparticles were in the nanometric range, the particle size and particle size range of ZCNN was less compared to ZNN indicated more surface area of ZCNN. Among all the nanoparticles prepared, percentage yield, loading efficiency, in vitro drug release and zone of inhibition was found to be more for ZCNN. Thus, the results suggested that ZCNN act as promising drug delivery systems with better in vitro characteristics compared to other nanoparticles with increased therapeutic activity of neomycin.
Highlights
Nanotechnology deals with design, characterization and application of various structures, devices and systems by controlling the size and shape at nanometric scale
Neomycin (Gift sample from Natco pharma Pvt limited, Hyderabad), chitosan (Sigma Aldrich, Hyderabad), agar, beef extract, (Himedia Pvt.limited, Mumbai), methanol, Polyethylene glycol (PEG) 400 (M.wt.420) and PEG 4000 (M.wt.3000), acetic acid (Sdfine, Mumbai), Bacillus subtilis, Staphylococcus aureus & Escherichia coli, Pseudomonas aeruginosa obtained from NCL, Pune
Compared with pure zinc nanoparticles (ZN) and pure chitosan nanoparticles (CN). These zinc chitosan neomycin nanoparticles were formulated to get maximum loading efficiency, invitro drug release by diffusion studies and agar cup plate method. It is evident from the Transmission Electron Microscopy (TEM) microphotographs (Figures 1 and 2) that ZCNN are more spherical in shape with smooth surface when compared to zinc neomycin nanoparticles (ZNN)
Summary
Nanotechnology deals with design, characterization and application of various structures, devices and systems by controlling the size and shape at nanometric scale. Nanoparticles can be defined as sub-micron sized colloidal particles composed of synthetic or semi-synthetic polymers having size range of 1 nm to 1000nm [1]. They contain macromolecular materials in which the active principle (drug / biologically active agent) is dissolved or entrapped or encapsulated or adsorbed or attached [2]. Nanoparticles can be up taken by the cells and can reach every cell to produce effective delivery when compared with conventional carrier [3] These nanoparticles when coated with polymers provide an increased therapeutic benefit by minimizing the side effects [4]. These enable the drug to enhance the bioavailability, decrease the toxicity [5], decreases the frequency of administration, drug targeting [6]
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