Abstract
Here, we present a highly efficient approach for synthesizing tetrazole-linked quinazoline derivatives through a sequential Ugi-4CR/Staudinger/Aza-Wittig/cyclization reaction. This method allows for the synthesis of diverse compounds with readily available starting materials and mild reaction conditions. The resulting compounds possess both tetrazole and quinazoline moieties, which have potential biological activities. Furthermore, we evaluated the inhibitory effects of selected compounds against Microcystis aeruginosa FACHB905 and observed certain bioactivities.
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