Abstract
AbstractA new series of oxazole linked pyrazole chalcone derivatives (9 a–j) has been developed, prepared and tested for in vitro anticancer activity against SiHa, A549, MCF‐7, and Colo‐205 cancer cell lines with etoposide employed as a positive control. The IC50 values of the synthesized compounds vary from 0.01±0.0081 μM to 11.6±6.10 μM, while the IC50 values of the positive control range from 0.14±0.017 μM to 3.11±0.11 μM, respectively. Six compounds such as 9 a, 9 b, 9 c, 9 d, 9 i, and 9 j have showed more potent activity than the others. Based on the docking simulations conducted on Human Topoisomerase II, it is evident that compounds 9 a, 9 b, 9 c, and 9 d exhibited superior binding affinity and interaction profiles compared to other compounds analyzed in this in silico study.
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