Abstract
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff.
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