Design and Synthesis of Novel 1,2,3‐triazolyl‐pyrimidinone Hybrids as Potential Anti‐HIV‐1 NNRT Inhibitors

Abstract

A novel series of 2‐((1H‐1,2,3‐triazol‐4‐yl)methylthio)‐5‐chloro‐6‐phenylpyrimidin‐4 (3H)‐one derivatives has been synthesized and studied their molecular docking as well as vitro assay as an anti‐human immunodeficiency virus type‐1 non‐nucleoside reverse transcriptase inhibitors. The synthetic approach was started from the reaction of aldehydes, ethylchloroacetate, and thiourea to give the 6‐aryl‐5‐chloro‐2‐thiouracils derivatives. Then, reaction of the later compounds with propargyl bromide followed by azide cycloaddition reaction (click reaction) led to the formation of the title compounds in good yields. The obtained derivatives were studied as anti‐human immunodeficiency virus type‐1 non‐nucleoside reverse transcriptase inhibitors. It was found that these compounds might have potent reverse transcriptase inhibition activity.