Design and synthesis of new thiazoles by microwave-assisted method: Evaluation as an anti-breast cancer agents and molecular docking studies

Abstract

A series of novel thiazole analogues were designed and synthesized by the microwave-assisted multicomponent reaction of thiocarbohydrazide, aldehydes with substituted phenacyl bromides. Structures of all the synthesized compounds were in good agreement with their spectral (1H and 13C NMR, FTIR, Mass) and analytical data. The target thiazole compounds were screened for their in vitro cytotoxic activity by testing against MCF-7, MDA-MB-231/ATCC, HS 578 T, BT-549, T-47D and MDA-MB-468 Breast cancer cell lines. From the in vitro results, it was found that the compound 4b has potent activity against MDA-MB-231/ATCC cell line. Docking studies were also done on these compounds to probe the possible binding site interactions which corroborated well with the in vitro results.