Abstract
Based on thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) thioether, we designed and synthesized fast-response fluorescent probes for discriminative detection of biothiols and Cys/Hcy. Probes treated with GSH/H2S could only release one emission; while reactions with Cys/Hcy generated two. Compared with probe 1, probe 2 exhibited good stability and high sensitivity toward Cys/Hcy in PBS buffer. Moreover, 2 could eliminate the effect of probe consumption by GSH/H2S when used to selectively detect Cys/Hcy and was applied for selective bioimaging of Cys in living mammalian cells successfully.
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