Abstract
The design strategy and synthesis of cis-bicyclo[4.4.0]decane (cis-decalin) derivatives as conformation-based probes of electrostatic interactions in H 2 O are described. The molecules were designed so that formation of an intramolecular electrostatic interaction occurs in only one of two low-energy conformers; hence, the conformational equilibrium of a given molecule is under control of the electrostatic interaction, which can be determined accurately with NMR studies
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