Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine

Abstract

An orally potent human renin inhibitor (1a) containing a novel amino acid, (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid named cyclohexylnorstatine, has been designed from the angiotensinogen transition-state and synthesized.