Design and synthesis of actinide specific chelators: Synthesis of new cyclam tetrahydroxamate (CYTROX) and cyclam tetraacetonylacetone (CYTAC) chelators

Abstract

Molecular modeling shows that two new chelators, the cyclam tetrahydroxamate, 1, and the cyclam tetraacetonylacetone derivative, 2, have potential for the binding of plutonium (IV). The synthesis of these chelators has been achieved using short sequences from readily available cyclam. Both the details of the molecular modeling and the synthetic route to these molecules are described.