Design and synthesis of a new magnetic aromatic organo-silane star polymer with unique nanoplate morphology and hyperthermia application

Abstract

In this study, new statistical magnetic organo-silane star polymers were designed, synthesized based on different surface functionalization processes of Fe3O4 magnetic nanoparticles and conducting the polymerization reaction between phenylenediamine derivatives and dichlorophenylsilane on their functionalized surfaces. Fourier-transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX), field-emission scanning electron microscope (FE-SEM) and transmittance electron microscope (TEM) images, X-ray diffraction (XRD) pattern, thermogravimetric (TG) analysis, vibrating-sample magnetometer (VSM), and dynamic light-scattering (DLS) and zeta potential measurements were employed to characterize the structural features. Based on the MTT assay and considering the highest concentration (1000 μg mL−1) of statistical magnetic organo-silane star polymer based on p-phenylenediamine as model derivative, the cell viability percentage of was reported 89.7%. In addition, the hyperthermia performance of this magnetic star polymer was evaluated by its exposure to an alternating magnetic field (AMF). Given the obtained results from different concentrations, the highest specific absorption rate (66.18 W g−1) was determined for 0.5 mg mL−1 of prepared sample. Therefore, it can be concluded that this new magnetic nanocomposite can be considered as an efficient agent for the next generation of therapeutic researches.