Design and Synthesis of a New Furanosic Sialylmimetic as a Potential Influenza Neuraminidase Viral Inhibitor

Abstract

A furanosic derivative has been identified as a simple sialylmimetic and synthesized, representing the first step in the development of a new series of furanosic sialic acid's mimetics as potential inhibitors of influenza virus neuraminidase. The structure was tested on a molecular simulating environment before proceeding with synthetic pathways. NA of both virus A and B is highly conserved in amino acid sequence variation. New and specific NA inhibitors, anti influenza drugs effective against both A and B influenza virus strains, have been implemented by developing transition state mimic molecules of the cleavage (13) mechanism of terminal sialic acid from any glycoconjugates that allow the infective process to take place. The difficulty in designing specific inhibitors is related to the necessity of building ex novo a molecule that could establish binding interactions in the NA active site, the same which sialic acid