Abstract

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-<scp>d</scp>-glucopyranosyl]-5<i>H</i>,13<i>H</i>-benzo[<i>b</i>]thienyl[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole-5,7(6<i>H</i>)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model.

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