Abstract
Several drugs have been used for the treatment of coronavirus disease (COVID-19); however, these drugs have not produced any effect against COVID-19. In the search of a clinical alternative, the aim of this research was to synthetize a 3,2'-indane]-1',3'-dione (compound 6) from 2,4-Dinitrophenyl hydrazine to evaluate their interaction with COVID-19 (6UL7) using either chloroquine and remdesivir as controls in a theoretical model. The results showed that compound 6 have a different affinity by 6UL7-protein surface compared with either chloroquine and remdesivir. In addition, other data showed low binding energy for 6 compared with both hydroxychloroquine and remdesivir. In conclusion, this phenomenon suggests that compound 6 could exert some change in the biological activity of COVID-19.
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