Abstract
6-Fluoropurine acyclonucleosides 6 and 7 have been prepared as potential prodrugs of acyclovir and ganciclovir. It has been found that compounds 6 and 7 are 11.6 and 7.6 times more efficiently metabolized to acyclovir and ganciclovir by adenosine deaminase than the corresponding 6-aminopurine acyclonucleosides 4 and 12, respectively.
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