Abstract
The design and synthesis of 10-oxo derivative of N-cyclopropylmethyl-(−)-6β-acetylthio dihydronormorphine ( 4) are described. The result of pharmacological assays indicate that compound 4 acts as a μ-opioid receptor antagonist and κ-opioid receptor agonist which is suggested to be more potent analgesic action than that of 1 and morphine through an activation of κ-opioid receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
