Design and Superior Performance of a New Endotracheal Tube to Avoid the Asphyxiation of Premature Infants.

Abstract

Background Neonatal endotracheal intubation attempts often fail, with failures typically attributable to unintended esophageal intubation, with asphyxia, brief or prolonged, as the consequence. Standard-of-care neonatal endotracheal tubes have changed little over recent decades, even as the gestational age of neonates thought eligible for resuscitation and intensive care has decreased. Methods A new neonatal endotracheal tube waspatterned after the soft steering mechanism of a two-string fishing line trocar.The new tuberemains patent throughout the intubation for air movement and CO2 detection and allows for a finger on the intubator's hand to stiffen, curve, and elevate the tip of the tube over the epiglottis and into the trachea without occluding the vision through a laryngoscope. Thistube's engineering principles were studied prospectively in a controlled open-label pilot studyin premature infants. Infantswereobserved during 12 intubationsin a one-to-one comparison with standard practice. Results The new design in comparison to a conventional neonatal endotracheal tube(CNETT) was found to be superior. The average intubation time (mean 36.6 sec, median 30 sec) was shorter (mean 44.6 sec, median 45 sec) in the new design. Intubation attempts were fewer (0 vs. 3), and unintended esophageal intubations were also fewer (0 vs. 4). Conclusion Tracheal intubation of premature infants with the new soft-steering mechanism endotracheal tube was associated with less asphyxia, fewer intubation attempts, and fewer esophageal intubations.