Abstract
Polyoxometalates (POM) are a class of inorganic compounds with various structures and remarkable electrical, magnetic and optical properties. Ion-pair complexes formed with some organic cations have high lipophilicity and they can be used as ionophores for PVC matrix membranes with active recognition function. The present study describes the construction and characterization of selective membrane sensors based on electroactive material incorporated in PVC matrix. They have been employed for the determination of ranitidine and nizatidine by using their complexes with silicotungstic acid as ionophores. The composition of the membrane has been optimized. The linear response range for both sensors was between 10-1-10-5M with quantification limits of 2.83�10-6M for ranitidine and 3.43�10-6M for nizatidine, and a response time shorter than 50 seconds. The new electrodes have been used for the potentiometrical determination of ranitidine and nizatidine in pharmaceutical products.
Highlights
Polyoxometalates (POM) are a class of inorganic compounds with various structures and remarkable electrical, magnetic and optical properties
Optimization of membrane sensor composition The optimal composition of the selective membrane was achieved by varying the mass ratio of the ionophore, polyvinyl chloride (PVC) and plasticizer to the proportion that exhibited the best performance characteristics
Two potentiometric sensors have been constructed based on ion pair complexes of ranitidine and nizatidine with silicotungstic acid as ionophores
Summary
Polyoxometalates (POM) are a class of inorganic compounds with various structures and remarkable electrical, magnetic and optical properties. Ion-pair complexes formed with some organic cations have high lipophilicity and they can be used as ionophores for PVC matrix membranes with active recognition function. The present study describes the construction and characterization of selective membrane sensors based on electroactive material incorporated in PVC matrix. They have been employed for the determination of ranitidine and nizatidine by using their complexes with silicotungstic acid as ionophores. The linear response range for both sensors was between 10-1-10-5M with quantification limits of 2.83·10-6M for ranitidine and 3.43·10-6M for nizatidine, and a response time shorter than 50 seconds. The new electrodes have been used for the potentiometrical determination of ranitidine and nizatidine in pharmaceutical products
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
