Abstract
Changes in blood composition are often closely related to physiological and pathological lesions in the body, and the detection of cells can help early diagnosis, treatment and prognosis. A microfluidic chip for cell detection was developed based on pneumatic microvalve and micropump, whose main functions include quantitative shunting, micro mixing with large volume ratio, impedance test and absorbance test, etc. The overall structure includes a cover plate, a middle layer and a substrate. The cover plate and the substrate were made of the borosilicate glass, and the middle layer was fabricated with organic polymer PDMS. The mixing performance of inner ribbed mircomixer and the influence of key parameters on the performance were investigated. The simulation results show that the inner ribbed micromixer has excellent mixing performance.
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