Abstract
In order to realize high performance particles and biomolecules handling systems, micro flow cell realizing three-dimensional (3-D) sheath flow was designed and the first prototype was fabricated. A finite element fluidic analysis is applied to realize optimal design of the flow cell. Especially, the structure of the sample injection part was considered to realize 3-D sheath flow. The high resolution flow monitoring method was studied and was applied to evaluate the flow behavior in the first prototype. The results indicated that the two steps introduction of the carrier flow is quite effective to put the sample flow away from the channel wall. This is very useful to avoid adsorption of the particles and the biomolecules on the wall due to the small flow rate near the wall. A simple micro flow switch for biomolecular separation is also proposed.
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