Abstract
In the pharmaceutical and fine chemical industries, spherical particles are highly valuable due to their numerous applications; however, they are hindered by traditional methods requiring intricate devices, high energy consumption, and biohazardous solvents. In this study, we constructed a strategy for the design of spherical particles based on thermal-induced liquid–liquid phase separation at the microscopic molecular level. Based on this strategy, high-performance spherical particles were successfully prepared in water by a simple heating-quenching operation. Moreover, this strategy could also control the solid structure of particles by utilizing intermolecular interactions to meet the requirements of various application scenarios. In the case of fenofibrate, the equipment was simplified, the use of organic solvents was avoided, and the powder properties, filtration properties, and tableting performance of the product were significantly enhanced compared to those reported literature. This work elucidated the design and green production of new crystalline/amorphous materials with versatile functions.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
