Abstract
Acteoside (ACT) belongs to a type of phenylethanoid glycosides (PhGs), and it is worthy of obtaining high-purity due to its significant medicinal functions. In this study, a novel class of MIMs was designed and synthesized with PVDF membranes as the base membrane for high selective separation and enrichment of ACT. The effects of the different functional monomers, the amounts of functional monomers, crosslinking agents, and initiators on the separation properties of MIMs were investigated. Furthermore, adsorption ability, permeation capacity, and reusability of MIMs were discussed for ACT. It indicated that MIM7 was the optimal performance of MIMs. The adsorption ability of MIM7 for ACT was 62.83 mg/g, and the selectivity factor (α) of MIM7 was up to 2.74 and its permeability factor (β) was greater than 2.66. Moreover, the adsorption amount of MIM7 was still more than 88.57% of the initial value after five cycles. As an ACT imprinted layer of MIMs only had recognition sites for ACT molecules, which recombined with the recognition sites in the membrane permeation experiment, ACT molecules penetration was hindered. However, the analogs of ECH successfully passed MIMs. It indicated that the selective MIMs for ACT followed the mechanism of delayed permeation. This work provides an important reference for the high permselective separation of natural products.
Highlights
Phenylethanoid glycosides (PhGs) are the main active ingredients in Cistanche tubulosa (Wang et al, 2017; Yan et al, 2017), and the research have indicated that it has the functions of kidney-replenishing, anti-oxidation, anti-tumor, anti-aging, and improving memory
A kind of ACT-molecularly imprinted membranes (MIMs) based on a polyvinylidene fluoride (PVDF) membrane was developed for the selective separation of ACT
The optimal synthesized conditions of MIMs were prepared by using ACT as a template molecule, 4-VP as a functional monomer, EGDMA as a crosslinking agent, and AIBN as initiator, and their molecular ratio was 2:60:40:1
Summary
Phenylethanoid glycosides (PhGs) are the main active ingredients in Cistanche tubulosa (Wang et al, 2017; Yan et al, 2017), and the research have indicated that it has the functions of kidney-replenishing, anti-oxidation, anti-tumor, anti-aging, and improving memory The main separation and purification methods of PhGs are the chromatography, the membrane separation technique, and adsorption method (Han et al, 2012; Dong et al, 2015; Pei et al, 2019; Xu et al, 2019b). High-speed countercurrent chromatography has low yield and low efficiency. The disadvantages of adsorption methods are high solvent consumption and low yield. The advantages of membrane separation technology are high separation efficiency, low energy consumption, and strong applicability (Zhang et al, 2018; Hong et al, 2019; Ding et al, 2020; Sun et al, 2020). Membrane separation technology has the problem of poor selectivity and low separation purity for natural products. It was of great significance to improve the membrane selectivity
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