Abstract
The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of plasticizer and percent coating weight gain was investigated to characterize the time lag. The developed formulation of FL SMEDDS capsules coated with ethyl cellulose showed time lag of 5-7 h which is desirable for chronotherapeutic application.
Highlights
The key to the success of any drug delivery system depends upon the development of formulations that accomplish the therapeutic needs associated with particular pathological condition or disease state (Lemmer, 1991)
After 48 h, the mixtures were centrifuged at 3000 rpm for 5 min (Research Compufuge, Remi, India) and an excess insoluble FL was discarded by filtration using a membrane filter (0.45 μm, 13 mm, Whatman, Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application
FL Self-microemulsifying drug delivery systems (SMEDDS) capsules were loaded with different weight gains of the coating polymer viz. 2.5%, 5% and 10%
Summary
The key to the success of any drug delivery system depends upon the development of formulations that accomplish the therapeutic needs associated with particular pathological condition or disease state (Lemmer, 1991). It has been observed that many physiological functions (e.g. blood pressure, hormonal levels) and pathophysiological. Such a delivery approach is termed as chronotherapeutic (chronos-time) (Mandal et al, 2010; Youan, 2004)
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