Abstract
Biological cell magneto-permeabilization is the phenomenon when the membrane of the cell increases permeability to molecules to which it was initially impermeable due to the exposure to high pulsed magnetic fields. Flexible high power electronics systems are required for triggering this effect. In this work, we have designed a high power (938 A, 2 kV) pulsed magnetic field generator (up to 5.5 T), which generates 10 μs–100 μs pulses with predefined repetition frequency of 1 Hz–100 Hz. We have applied SPICE and COMSOL Multiphysics modelling for design and development of the system, which showed a good agreement with the experimental results. The snubber and crowbar circuitry has been implemented for compensation and dampening of the transient processes on the switches, which allowed limiting the overvoltage to 0.25 kV. The multilayer inductor structure and design considerations are also presented in the study.DOI: http://dx.doi.org/10.5755/j01.eie.23.2.17994
Highlights
Application of pulsed power technologies for transdisciplinary research in areas such as material science, biomedicine, aerospace or plasma science has expanded widely in the past 25 years, accompanied by the development of new specific pulsed power setups to meet the requirements of the experiments [1], [2]
Biological effects of pulsed magnetic field (PMF) are pulse dependent [12], [13], in this case the biological phenomenon determines and raises the requirements for a pulsed system that is needed for research
The generator circuitry has been optimized for inductive load handling and damping of the transient processes on the MOSFET switches
Summary
Application of pulsed power technologies for transdisciplinary research in areas such as material science, biomedicine, aerospace or plasma science has expanded widely in the past 25 years, accompanied by the development of new specific pulsed power setups to meet the requirements of the experiments [1], [2]. The most straightforward approach for development of a pulsed magnetic field generator is a spark gap switch based circuit topology, which discharges a high power capacitor through a multilayer inductor [8], [9]. This approach does not allow a flexible control of the pulse shape and the pulse is bipolar (fading sinusoidal oscillation), which further increases the complexity of interpretation of the biological effect [8]. We optimize the circuit for inductive load handling by damping the transient processes (limiting the overvoltage and overcurrent), which allows application of an array of high power MOSFET switches
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