Design and optimization of Eleutherine palmifolia extract-loaded SNEDDS using HLB approach

Abstract

The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system (SNEDDS) based on Hydrophilic Lipophilic Balance (HLB) value. This study aimed to prepare and characterize the Eleutherine palmifolia (E. palmifolia) extract-loaded self-nanoemulsifying drug delivery system (SNEDDS) using a Hydrophilic Lipophilic Balance (HLB) approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants (tween 20, tween 80) mixed with two lipophilic surfactants (Span 20 and Transcutol). The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol [PEG] 400. The characteristics of the optimal formulation showed transmittance value of 97.97 ± 0.17%; emulsification time on artificial intestinal fluid (AIF) media of 52.00 ± 0.03 seconds; artificial gastric fluid (AGF) media of 50.00 ± 0.03 seconds; pH of 8.90 ± 0.06; viscosity of 32.81 ± 0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400. Keywords : SNEEDS; self-nanoemulsifying; formulation; Eleuthe