DESIGN AND OPTIMIZATION OF CEFIXIME TRIHYDRATE SUSTAINED RELEASE MATRIX TABLETS USING DIFFERENT POLYMERS

Abstract

The objective of the present work is to design sustained release matrix tablets of Cefixime Trihydrate by incorporating drug in a matrix made up of release retardant polymers, which p rolongs the drug release leading to minimize the peak and valley effect in the plasma and provide patient convenience. The ef fect of combination of polymers on parameters like release pattern, release mechanism of the drug were studied. Total nine formulat ions each containing 200 mg of drug were prepared by direct compression method. The formulations F - 1, F - 2, F - 3 were prepared 1:1 drug to polymer ratio using HPMC, sodium CMC and Ethyl cellulose. F - 4 was prepared by 1:1 ratio of HPMC and sodium CMC ,F - 5 was prepared by 1:1 ratio of HPMC and Ethyl cellulose, F - 6 was prepared by in 1:1 ratio of sodium CMC and Ethyl cellulose, F - 7, F - 8, F - 9 were prepared by using polymers HPMC, sodium CMC and Ethyl cellulose in the ratios of (0.5:0.5:1), (0.5:1:0.5), (1:0.5:0. 5). Designed matrix tablets evaluated for various pre - compression and post - compression parameters. Formulation F - 5(1:1 ratio of HPMC and Ethylcellulose) showed 102.15 % release at the end of 12 hours and it is selected as the best formulation. All Formulat ions follows zero order with non fickian diffusion method.