Abstract
Drug delivery via liposomes has the potential to expand the therapeutic window by targeting and releasing drug at the disease site while minimizing drug concentrations elsewhere in the body. [ 1 ] In a liposome, a single bilayer defi nes the interior space, regulates release of the liposome contents, and protects the contents from the environment. However, fi nding a bilayer composition that provides the necessary physical integrity, drug retention, specifi c targeting and rapid contents release at the disease site has been problematic. Despite 40 years of research, only liposomal doxorubicin and amphotericin B are clinically available. Many drugs, including the antibiotic ciprofl oxacin, [ 2 , 3 ]
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