Abstract

Noninvasive monitoring of blood flow in the carotid artery is important for evaluating not only cerebrovascular but also cardiovascular diseases. In this paper, a wireless neckband ultrasound Doppler system, in which two 2.5-MHz ultrasonic sensors are utilized for acquiring Doppler signals from both carotid arteries, is presented for continuously evaluating blood flow dynamics. In the developed wireless neckband Doppler system, the acquired Doppler signals are quantized by 14-bit analog-to-digital-converters running at 40 MHz, and pre-processing operations (i.e., demodulation and clutter filtering) are performed in an embedded field programmable gate array chip. Then, these data are transferred to an external smartphone (i.e., Galaxy S7, Samsung Electronics Co., Suwon, Korea) via Bluetooth 2.0. Post-processing (i.e., Fourier transform and image processing) is performed using an embedded application processor in the smartphone. The developed carotid neckband Doppler system was evaluated with phantom and in vivo studies. In a phantom study, the neckband Doppler system showed comparable results with a commercial ultrasound machine in terms of peak systolic velocity and resistive index, i.e., 131.49 ± 3.97 and 0.75 ± 0.02 vs. 131.89 ± 2.06 and 0.74 ± 0.02, respectively. In addition, in the in vivo study, the neckband Doppler system successfully demonstrated its capability to continuously evaluate hemodynamics in both common carotid arteries. These results indicate that the developed wireless neckband Doppler system can be used for continuous monitoring of blood flow dynamics in the common carotid arteries in point-of-care settings.

Highlights

  • Noninvasive monitoring of blood flow in the common carotid arteries is important for evaluating cerebrovascular diseases [1,2] and cardiovascular diseases [3,4]

  • In the in vivo study, the neckband Doppler system successfully demonstrated its capability to continuously evaluate hemodynamics in both common carotid arteries. These results indicate that the developed wireless neckband Doppler system can be used for continuous monitoring of blood flow dynamics in the common carotid arteries in point-of-care settings

  • In carotid Doppler ultrasonography, spectral broadening with an elevated peak systolic velocity (PSV) on a pulsed-wave spectral Doppler waveform is correlated with the degree of carotid stenosis [8,9,10,11]

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Summary

Introduction

Noninvasive monitoring of blood flow in the common carotid arteries is important for evaluating cerebrovascular diseases [1,2] and cardiovascular diseases [3,4]. Doppler ultrasonography is a popular tool for measuring blood flow velocity and its variability in the common carotid arteries [5,6,7]. In carotid Doppler ultrasonography, spectral broadening with an elevated peak systolic velocity (PSV) on a pulsed-wave spectral Doppler waveform is correlated with the degree of carotid stenosis [8,9,10,11]. Carotid Doppler ultrasonography can provide quantitative functional measurements of blood flow, e.g., the resistive index, RI, which is a hemodynamic parameter reflecting local wall extensibility and related vascular resistance [12,13,14].

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