Abstract

Simple and useful methods are described herein for a portable and multichannel preamplifier circuit. These procedures include mainly operational amplifier selection, offset voltage reduction, active guarding circuit, selectable reference node, and grounded plate arrangement. A six-channel preamplifier board is designed and fabricated for intracortical activities recording using commercial components. The preamplifier has been successfully tested in vivo to process cortically derived extracellular evoked potentials under anesthetized rat. Results from both simulated circuit testing and practical animal measuring indicate that a high-quality recording can be obtained by adopting the presented circuits. This method needs only ready-made materials, general know-how, and a few components and is simple even for a nonelectronic engineering researcher in-house. The proposed preamplifier can be easily expanded by combining other post-processing circuits or recording devices. This preamplifier can also be easily modified and applied to the analogy front-end (AFE) of telemetric recording system, other related electrophysiological or physiological studies.

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