Abstract
Optical coherence tomography (OCT) is a widely used biomedical imaging tool, primarily in ophthalmology to diagnose and stage retinal diseases. In order to increase access for a wider range of applications and in low resource settings, we developed a portable, low-cost OCT system that has comparable imaging performance to commercially available systems. Here, we present the system design and characterization and compare the system performance to other commercially available OCT systems. In addition, future cost reductions and potential additional applications of the low-cost OCT system are discussed.
Highlights
Optical coherence tomography (OCT) is a non-invasive optical imaging technique that utilizes low coherence interferometry to detect backscattered light from tissue to produce depth resolved images up to a few millimeters below the surface [1]
OCT has been adopted as the gold standard for retinal imaging in ophthalmology, the high cost of clinical systems has restricted access to mostly large eye centers and laboratories [5]
Development towards a low-cost, portable OCT system could significantly increase the ease of access, in low resource settings, and expand the use of OCT to a wider range of applications which were previously cost prohibitive
Summary
OCT is a non-invasive optical imaging technique that utilizes low coherence interferometry to detect backscattered light from tissue to produce depth resolved images up to a few millimeters below the surface [1]. OCT is an emerging technology for a wide range of biomedical applications including intravascular OCT (IV-OCT) for identifying at-risk atherosclerotic plaques, detection of neoplasia in the gastrointestinal tract and other organ systems, real-time surgical guidance, and high resolution imaging of biological specimens [2]. Due to its fast speed and high sensitivity, spectral domain OCT (SD-OCT) is currently recognized as the state of the art technology for acquiring in vivo, cross sectional image of ocular tissues to identify retinal morphology and abnormalities [3, 4]. OCT has been adopted as the gold standard for retinal imaging in ophthalmology, the high cost of clinical systems (up to $150,000) has restricted access to mostly large eye centers and laboratories [5]. Development towards a low-cost, portable OCT system could significantly increase the ease of access, in low resource settings, and expand the use of OCT to a wider range of applications which were previously cost prohibitive
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