Abstract
This paper presents the design, simulation and low-cost fabrication of microfluidic channel for biomedical application. Channel is fabricated using soft lithography technique. Printed Circuit Board (PCB) is used to make the master for the channel. Channel pattern is transferred on PCB plate using toner transfer technique followed by ferric chloride etching. Paper also discusses, the issues involved in PCB based master fabrication and their viable solutions. Glass is used as substrate material and the channel is made of Sylgard 184 Polydimethylsiloxane (PDMS). Channel is interfaced with a syringe pump to observe the fluid flow. To predict the behavior of the channel, FEM simulation is performed using COMSOL Multiphysics 5.2a. There is a good match between the theoretical, simulation and test results. Finally, to test the biocompatibility of the channel, genomic DNA is passed through the channel and gel electrophoresis analysis is performed.
Highlights
Microfluidics deals with the study of devices that can handle the very small amount of liquid down to femtoliter with the help of small channels and reservoirs
The masters made of SU8 photoresist24–26, 3-D printing[27], Soldering wire[28], and, PCB29,30 are popular in the fabrication of microfluidic devices
We have presented the design, simulation, and fabrication of low-cost microfluidic channel for biomedical application
Summary
Microfluidics deals with the study of devices that can handle the very small amount of liquid down to femtoliter with the help of small channels and reservoirs. Present work deals with the design, simulation, and fabrication of low-cost microfluidic channel with a rectangular cross-section using PCB based master.
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