Design and Fabrication of Gold Nanoparticles for Anti-Asthma Drug Delivery

Abstract

Background and Aim: Nanoparticle drug delivery has recently found a special place in medicine and treatment. Different nanoparticles have different capabilities and functions. Gold nanoparticles are one of the most widely used nanoparticles and have many uses in pharmaceuticals and medical purposes, including diagnostic, therapeutic, and imaging methods, and due to their unique characteristics, such as high contact surface area compared to volume. Gold nanoparticles have many advantages over other nanoparticles such as their neutral nature, stability, high diffusion property, non-toxicity, environmental compatibility, optical adjustment. Our goal is to synthesize and characterization gold nanoparticles with specific applications to produce the best delivery system of drugs to the asthmatic lung. Methods: Turkevich method has been used for the synthesis of gold nanoparticles and approving studies have been done. Results: The produced GNP has the average diameter 100-200 nm and the Z-average was 137.9 d.nm and in positive charge area. PDI for GNP was 0.358. Conclusion: In this study, we were able to produce the applicable gold nanoparticles for carrying drugs to asthmatic bronchi. Gold nanoparticles easily reach target cells due to their high dispersion power. Drug side effects are reduced when gold nanoparticles are used in conjunction with the drug for drug delivery purposes. *Corresponding Authors: Alireza Taheri, Email: taheri@ilam-iau.ac.ir; Seyyed Shamsadin Athari, Email: ss.athari@zums.ac.ir Please cite this article as: Mehrabi Nasab D, Taheri A, Athari SS. Design and Fabrication of Gold Nanoparticles for Anti-Asthma Drug Delivery. Arch Med Lab Sci. 2020;6:1-7 (e4). https://doi.org/10.22037/amls.v6.32580