Abstract
In this study, a manual micro-valve system (dimension: w × h: 1000 × 50 μm with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. The working parts of the micro-valve and microfluidic channel were fabricated from Poly(dimethyl siloxane) materials. The aperture of each channel valve was manually manipulated by a screw and a support kit (made of Plexiglas® materials). This valve system was connected to a microfluidic device with two important modules: a multi-liquid mixing component and a micro-reactor (~5 μL of volume). The study on controlling liquid flows proved that this valve system was effective for the experiments on the flow mixing and delivering the reactants into the micro-reaction chamber in order. The results are the first step for the fabrication of liquid flow controllers in integrated microfluidic systems towards biological analysis applications.
Highlights
The micro/nano uidic devices are interested in biomedical and chemical analyses. e micro/nano uidics with very small channels have advantages such as: reducing the consumption of agents; increasing sensitivity thanks to small volume with large surfaceto-volume ratio [1, 2]
Regarding a micro uidic system, the add-on devices connecting to the micro uidic needs to be miniaturized, and all agents are injected into micro-channels by micro-pumps; the sequence of ow needs to be controlled by a micro-valve system [8, 9]
Typical studies [9,10,11] on micro uidics reported that it was easy to control the on/o chip ows based on a valve structure. ere are several commercial valve systems, e.g., the MUX WIRE system from Elve ow® company or LINEUPTM Series from Fluigent® company. ese valves systems are professional but quite expensive
Summary
The micro/nano uidic devices are interested in biomedical and chemical analyses. e micro/nano uidics with very small channels (μm size) have advantages such as: reducing the consumption of agents; increasing sensitivity thanks to small volume (micro/nano litter) with large surfaceto-volume ratio [1, 2]. Some models of “Lab-made” valves were designed for controlling liquid ows of micro uidic system in laboratories [12, 13]. Brett [9] designed and fabricated a manually actuated pin valve for controlling the uid ow (on/o ) within micro uidic channels [9].
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