Abstract
Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in TabletsM. Mathrusri Annapurna, B. Swathi, M. Siri Chandra and K. Tulasi
Highlights
Oral delivery of medication is most popular route because of the benefit of administration, patient compliance, and suppleness
The present research work was successful in improving the efficacy of zolpidem tartrate oral therapy as the drug release was extended for twelve hours reducing dosing frequency thereby improving patient compliance
The study revealed the applicability of Hydroxypropyl methylcellulose (HPMC) K100M, guar gum, and xanthum gum as rate-controlling polymers in matrix tablets
Summary
Oral delivery of medication is most popular route because of the benefit of administration, patient compliance, and suppleness. Extended-release oral drug formulations are used since the Sixties to increase patient compliance (Pogula et al, 2010). Extended releases adequate quantity of drug to induce the required blood concentration initially after the administration (loading dose, DL) for the required therapeutic response and more quantity of drug is free at a controlled rate (maintenance dose, DM) to keep up the same blood levels for a few fascinating amount of time (Pogula et al, 2010). The hypnotic effects of Zolpidem are reportable primarily within the 1st three hours post-dose which might result in subtherapeutic effects on sleep maintenance within the later portion of the night for a few patients (Hardman et al, 2001). Within the work, an endeavor has been created to develop once-daily extended release matrix tablets of zolpidem victimization supposed colloidal matrix materials adore HPMC K100M and natural gums like guar and xanthum gum
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