Design and Evaluation of Sustained Release Solid Dispersions of Verapamil Hydrochloride

Abstract

The Purpose of this study was to prepare and characterize solid dispersions of this antiarrhythmic drug Verapamil hydrochloride (VPH) with HPMCK4M, EudragitRSPO and their combination with a view to sustain its dissolution properties. Investigation of the properties of the prepared solid dispersions were performed using release studies and Fourier transform infrared (FT-IR). The results obtained showed that the rate of dissolution of Verapamil hydrochloride was considerably more sustained when formulated in solid dispersions with HPMCK4M and Eudragit RSPO as compared with pure drug and physical mixtures. FT-IR studies confirmed absence of any possible solid state drug and polymer interactions. In order to establish the mechanism and kinetics of drug release, the experimental data was fitted to different kinetic models likes zero order, first order, Higuchi’s model, korsmeyer peppa’s model. From the above research it may be concluded that HPMCK4M acts as a better release retardant for the model drug.