Abstract
The objective of present work is to develop proniosomal ocular gel of Levofloxacin and evaluation of their potential for sustained ocular delivery. The conventional liquid ophthalmic formulation is eliminated from the precorneal area immediately upon instillation and it is difficult to achieve good bioavailability of drug due to the tear production, non productive absorption, impermeability of corneal epithelium and transient residence time. As a result, frequent instillation of concentrated solutions is needed in order to achieve the desired therapeutic effects. The bioavailability can be enhanced by the use of vesicular systems such as Niosomes. But, Aqueous suspensions of Niosomes may exhibit aggregation, fusion, leaking of entrapped drug or hydrolysis of encapsulated drug, thus limiting the shelf life of the dispersion. The proniosomal approach minimises the above-mentioned problems and therefore there is ease of transfer, distribution, measuring and storage which makes proniosomes a versatile delivery system. Levofloxacin Proniosomal gel enhances the contact time and retention in the eye and provides sustained release action and better availability of drug.
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