Abstract
Objective: Appropriateness of administration and patient complaints are important factors in developing dosage forms, especially for children and elderly people. The goal of this research was to develop salbutamol sulfate granules that dissolve quickly to improve patient compliance. Methods: Five formulas (F1-F5) were prepared by wet granulation methods. Different type of excipients was used in the formulation like banana powder as super disinterring, mannitol, hydroxyl propyl methylcellulose; etc. The formulas were evaluated for flow properties, drug compatibility study by FTIR, drug content, and drug release profile. Results: The result revealed that the flowability of the five formulas has accepted flow properties; The FTIR studies of the formula F2 showed no drug-excipients interaction. All of the prepared formulas show an acceptable range of drug content, a rapid release of drug of about 95.2% within 10 min. These results indicate good and rapid release properties of salbutamol sulfate from fast dissolving granules. Conclusion: Salbutamol sulfate was successfully formulated as fast-dissolving granules by using banana powder.
Highlights
Fast dissolving dosage forms have witnessed a growth in demand over the last decade, and the field has become a rapidly growing area in the pharmaceutical industry
The results of the flowability test for salbutamol granules were shown in table 4, the bulk density values in the range (0.45 to 0.51) and tapped density between (0.52 to 0.59) respectively
The results of the flowability properties of five formulas showed improving to flow properties, improved flow rate and less friction within the bulk. This shows that the mixed mixes have excellent flow properties [15]; the improving of flowability properties could be attributed to the manufacturing process, the wet granulation process, in which the granules produced are more spherical and have better flow characteristics than powders [16]
Summary
Fast dissolving dosage forms have witnessed a growth in demand over the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. New drug delivery systems (NDDS) are attempting to improve drug molecule safety and efficacy by producing a convenient dosage form for administration to promote patient compliance. "Fast dissolving granules" is one such method. The need to give patients with a more traditional means of taking their medication when drinking water is impossible contributed to the idea for quick dissolving/disintegrating granules, as well as in specific instances such as motion sickness, sudden allergy attacks, or coughing. Geriatric, paralytic, nauseated, or non-compliant patients, recent technological advances have provided realistic dosing choices [2]
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