Design and Evaluation of a Complex Phytoceutical Formulation for Circulatory Diseases

Abstract

Although herbal/natural remedies have been, and are still being used, in the treatment of chronic degenerative diseases, little is known about basic principles –or theoryto combine these components and attain synergistic, gene modulating, as well as clinical health improving effects. This chapter is divided into six sections. Section 2 reviews the background which gives origin and establishes the Systemic Theory and Systemic Medicine. The section also provides the general precepts to structure Circulat -a complex herbal formulationfor the treatment of circulatory chronic degenerative diseases. Section 3 is an outline of an investigation into the aforementioned formulation’s role and capability to modulate various gene expression levels -in cultured human fibroblastsincluding those associated with diabetes. On the other hand, Section 4 presents a review of Circulat s clinical properties through a Diabetic Foot management Study. An abbreviated limited Phase 2 GSPECT evaluated Chronic Ischemic Disease –another circulatory chronic diseasestudy is presented in Section 5. Finally, Section 6 provides some conclusions concerning the use of a complex herbal formulation as well as some reflections on the future design of such compositions.