Design and efficacy of all-in-one sandwich-like multifunctional platform for drug delivery

Abstract

Through electrostatic and H-bonding interaction, polyelectrolyte could be self-assembled onto the medical devices via layer-by-layer (LBL) method. However, the built-in instability of LBL coating has seriously limited its further application. The polyphenols were incorporated into the polyelectrolyte coating, which provided various synergistic forces, including electrostatic, H-bonding, π-π stacking, and weak chemical cross-linking. The surface engineering of polyphenol-based sandwich-like films with polyethyleneimine and heparin via LBL self-assembly. This design improved the loading capacity and long-term release of drugs, such as heparin, rapamycin, and gentamicin sulfate. These experiments suggested enhanced durability of antithrombotic potential (over 90 days), good anti-inflammatory and anti-bacteria performances, and promotion of vascular healing. Therefore, all-in-one sandwich-like coatings might be a straightforward, versatile, and durable surface modification method for implantable medical devices.