Abstract
Abstract: Platinum-based anticancer drugs which are widely used in clinic have nearly 40 years history of research and application. In this review, we make a brief introduction of platinum-based anticancer drugs which have been used in clinic or still during the clinical trails, and summarized the drugs which were failed in clinical trails. We introduce the design and development methods of new generation platinum-based anticancer drugs consisting of platinum(II) complexes such as modified and improved trans -platinum(II) complexes, platinum(IV) complexes, and mono-functional platinum complexes. Coordination-saturation platinum complexes and multinuclear platinum complexes are discussed emphatically. This review has put forward some design methods of platinum-based anticancer drugs through listing some of the latest research results, and let readers understand the development of platinum-based anticancer drugs and the future direction of development.
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