Abstract
The main aim of this investigation is to design and develop matrix type transdermal patches of Propranolol Hydrochloride which is an anti-hypertensive drug. These matrix type transdermal patches were prepared by “Solvent Casting Technique” using drug, HPMC E15 and Eudragit L 100 in the ratio of 1:6, 1:6.5, 1:7, 1:7.5, 1:8, 1:8.5, 1:9, 1:9.5. All formulations carried 20%v/w of PEG-600 as plasticizer. The prepared patches were characterized for various physicochemical parameters like weight, thickness, folding endurance, drug content, percent moisture content, percent moisture absorption, in vitro drug release and ex vivo permeation. Among this 1:9 ratio was found to be an Optimized formulation and patches were prepared by using permeation enhancers (lemon grass oil, Eucalyptus oil, and clove oil). The cumulative amount of drug release in 12hrs for F7 formulation showed maximum and used for that formulation skin permeation on Goat abdominal skin. FTIR studies show no interaction between drug, polymer and other excipients. The drug permeation kinetics followed “First order” and “zero order” profile with diffusion mechanism.
Highlights
Transdermal drug administration generally refers to topical application of agents to healthy intact skin either for localized treatment of tissues underlying the skin or for systemic therapy
Transdermal drug delivery systems are defined as self-contained discrete dosage forms which applied on the intact skin, delivery the drugs through the skin, at controlled rate to systemic circulation
The results revealed that the moisture absorption and moisture content was found to be increase with increasing concentration of polymer HPMC E15 and Eudragit L 100.The small moisture content in the formulations help them to remain stable and from being a completely dried and brittle patch
Summary
Transdermal drug administration generally refers to topical application of agents to healthy intact skin either for localized treatment of tissues underlying the skin or for systemic therapy. For transdermal products the goal of dosage design is to maximize the flux through the skin into the systemic circulation and simultaneously minimize the retension and metabolism of the drug in the skin. Transdermal drug delivery systems are defined as self-contained discrete dosage forms which applied on the intact skin, delivery the drugs through the skin, at controlled rate to systemic circulation. Transdermal drug delivery system has many advantages over the oral route of administration such as Improves absolute bioavailability due to avoidance of first pass hepatic and gastrointestinal metabolism, Enhance therapeutic efficacy, reduced side effects due to optimization of blood concentration-time profile, Rapid termination of drug action by removal of drug application from the surfaces of the skin, Therapeutic agents delivered at controlled rate through skin into systemic circulation
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