Abstract
ABSTRACTThe aim of this study is to design and development of mesoporous silica for loading of drug (Paliperidone) in mesoporous silica and to enhance the solubility and dissolution rate of poorly water soluble drug (BCS Class II) eg. Paliperidone using mesoporous silica as a drug carrier. Mesoporous silica is synthesized by using sol gel method after loading of drug (Paliperidone) using wetness impregnation method, the dug loaded mesoporous silica sample characterized by Scanning Electron Microscopy, Transmission Electron Microscopy, BET surface area analysis, FTIR study, Differential Scanning Calorimetry, X-Ray powder Diffraction and dissolution study. Mesoporous silica has a drug-loading efficiency of up to 62.44%. Data relating to the dissolution of paliperidone and paliperidone-loaded SBA-15 in different dissolution media were obtained. The drug release of paliperidone in 120 minutes in a phosphate buffer of pH 6.8 was 30%, whereas the drug release of paliperidone-loaded SBA-15 was 96%. The in vivo study investigated that the mesoporous silica is used for surge dose drug delivery system.
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