Design and development of montmorillonite-sodium alginate microbeads for oral sustained delivery of cefaclor

Abstract

Drug administration via oral route is most suitable for drug delivery to patients. But this route is associated with several drawbacks such as high frequency of administration as well as gastric discomfort. To avoid these problems attempt was made to develop the sustained release system by using nanocomposite clay (MMT) and polymer (Na-Al) based microbeads for oral administration of CFR. The formulations were optimized and validated by using Box–Behnken design with 3 different levels of MMT, Na-Al and CaCl2 wherein the %EE and % drug release at 8 h were considered as dependent responses. The developed formulation was characterized by FT-IR, DSC as well as XRD. The optimized formulation was evaluated for % yield, swelling behavior, particle size, drug release and surface morphology by FESEM. The developed formulation showed physical interaction due to surface adsorption and intercalation of drug with that of MMT. The optimized formulation showed high yield, %EE and swelling behavior due to high amount of MMT and Na-Al. The particle size of the microbeads was below 500 µm and drug release takes place in sustained manner up to 12 h. Polymeric cross-linking and MMT stalking were observed in FESEM study indicated distinctive system. Drug release follow the non-fickian diffusion pattern coupled with matrix release as indicated by Korsemeyer-Peppas (n) value 0.72.