Design and Development of Mebendazole Lozenges by Natural Polymers

Abstract

Mebendazole is an anti-helminthic drug used to treat infections caused by worms. It works by keeping the worm from absorbing sugar (Glucose), So that the worm loses energy and dies. There are many dosage forms like syrups, tablets, ODT`s available in the market but still there is need for new dosage form which acts effectively and locally for paediatrics and geriatric people with difficulty in swallowing. The local acting mechanism of mebendazole makes it more suitable to formulate as lozenges. The hard candy lozenges were formulated using sugar as a base Xanthum gum, Guar gum and Neem gum are used as natural polymers. The usage of liquid glucose in the formulation made the lozenges smooth which helped in improving the elegance of the formulation. Stevia was used as sweetener. Sweetener along with flavours is used to mask taste of drug. The formulation of hard Candy lozenges was subjected to physico-chemical as well as in vitro drug release. Among all the formulations of hard candy lozenges formulation F7 had shown in vitro drug release of 99.9% at the end of 30min.