Design and Development of In-House Multichannel Applicator for HDR Vaginal Brachytherapy and Dosimetric Comparision with Single Channel Applicator.

Kesavan Govindaraj,Senthilkumar Shanmugam,Sowmiya Sampathrajan

doi:10.31557/apjcp.2019.20.12.3805

Kesavan Govindaraj, Senthilkumar Shanmugam + Show 1 more

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https://doi.org/10.31557/apjcp.2019.20.12.3805

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Abstract

Introduction:Endometrial cancer (EC) is a leading cause of female cancer in developed countries. The total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node dissection is the primary management of endometrial cancer. Afterwards vaginal brachytherapy can be preferred either alone or combined with external beam radiotherapy to avoid the vault recurrence. This study was to assess the in-house multichannel applicator for HDR vaginal brachytherapy and dosimetric compression with the single channel applicator through DVHs. The main objective of this study was to design and development of an in-house multichannel applicator for HDR vaginal brachytherapy and dosimetric compression with the single channel applicator through DVHs. Materials and Methods:The multichannel applicator is a solid cylinder with 3 cm diameter, 13 cm length. It has a central channel surrounded by eight channels with a periphery arrangement in a single circle. We randomly selected eleven patients with endometrial carcinoma and 7Gy/per fraction of HDR dose was prescribed to CTV. Retrospectively, two 3D inverse treatment plans were created for each patient, with single channel loading and multichannel loading and the dose distribution of both plans could be compared. CTV coverage, rectum and bladder doses were compared. Results:The DVH analysis showed statistically significant difference between single and multichannel plan, that is for D95 of CTV (p=0.008), D100 of CTV (p=0.004) and 2cc of CTV (p=0.003). The p value for 1cc, 2cc and V70 are 0.003, 0.003 and 0.003 for rectum. On the other hand, bladder DVHs showed large difference between single and multichannel plan yet it is not statistically significant, and the p values for 1cc, 2cc and V 80 are 0.012, 0.009 and 0.225. Conclusion:The authors conclude that in house multichannel applicator with 3D inverse treatment planning techniques improves the dosimetric advantage over single channel applicators.

Highlights

Endometrial cancer (EC) is a leading cause of female cancer in developed countries
The total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node dissection is the primary management of endometrial cancer
The authors conclude that in house multichannel applicator with 3D inverse treatment planning techniques improves the dosimetric advantage over single channel applicators

Summary

Introduction

Endometrial cancer (EC) is a leading cause of female cancer in developed countries. The total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node dissection is the primary management of endometrial cancer. Two 3D inverse treatment plans were created for each patient, with single channel loading and multichannel loading and the dose distribution of both plans could be compared. Results: The DVH analysis showed statistically significant difference between single and multichannel plan, that is for D95 of CTV (p=0.008), D100 of CTV (p=0.004) and 2cc of CTV (p=0.003). Bladder DVHs showed large difference between single and multichannel plan yet it is not statistically significant, and the p values for 1cc, 2cc and V 80 are 0.012, 0.009 and 0.225. Endometrial cancer (EC) is a leading cause of female cancer in developed countries It is the fifth most common cancer worldwide and eighth leading cause of death from cancer in women (Sebastià et al, 2017; Ahmedin et al, 2009). Radiotherapy can be delivered with external beam radiation therapy (EBRT) and /or brachytherapy (Henry et al, 2004; Small et al, 2012)

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