Design and Development of highly filled calcium sulfate-poly lactic acid biocomposites as feedstock for low-cost fused filament fabrication

Abstract

Three-dimensional (3D) printing has been used as a promising technology in biomedical sciences and engineering. However, there is a lack of ready-to-use feedstock for biomedical applications. In this work, a series of PLA biocomposite filled with calcium sulfate (CaS) particles up to a maximum content of 40 wt% has been prepared by solvent casting method and subsequently processed into filament form through the melt compounding method. The objective of this study was to investigate the processibility of composite filament with maximum ceramic content through fused filament fabrication (FFF) process to improve the mechanical, thermal and biological performance of virgin PLA for biomedical application. The composite filament was extruded at a temperature of 160 °C at a constant speed with an average diameter of 1.70 ± 08 mm, compatible with the 3D printer's feeding system. Morphological, thermal, mechanical, and crystallization analysis using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and thermogravimetric (TGA) analysis was performed on the extruded filament to evaluate the effect of ceramic content in the polymeric matrix. The thermal stability was improved upon addition of CaS particles into the PLA matrix. Subsequently, PLA-CaS solid specimen was 3D-printed and characterized for its mechanical, and geometrical accuracy. The maximum compressive strength obtained is 115 MPa for 20% ceramic loading, which then decreases with increased ceramic content. The biocompatibility test using MC3T3E1 cells confirmed zero cytotoxicity and cell grows well on all PLA and composite specimen. The results revealed that the composite biomaterials could be easily printed even at high ceramic loading and maintain their structural integrity and stability during the additive manufacturing process. These composites could be potential candidates for various biomedical applications, such as bone scaffolds and bioresorbable screws for Anterior Cruciate Ligament (ACL) reconstruction.