Abstract
The most affected disease in recent years is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) that is notable as COVID-19. It has been started as a disease in one place and arisen as a pandemic throughout the world. A serious health problem is developed in the lungs due to the effect of this coronavirus. Sometimes it may result in death as a consequence of extensive alveolar damage and progressive respiratory failure. Hence, early detection and appropriate diagnosis of corona virus in patient’s body is very essential to save the lives of affected patients This work evolves a Silicon (Si) based label-free electrical device i.e. the reduced graphene oxide field-effect transistor (rGO FET) for SARS-CoV-2 detection. Firstly rGO FET functionalized with SARS-CoV-2 monoclonal antibodies (mAbs). Then the rGO FET characteristic response is observed to detect the antibody-antigen reaction of SARS-CoV-2 with different molar ranges. The developed GFET shows better performance towards the drain current and limit-of-detection (LoD) up to 2E-18 M. Therefore, we believe that an intense response was observed than the earlier developed devices and signifies impressive capability for subsequent implementation in point-of-care (PoC) diagnostic tests.
Highlights
Emerging contagious diseases, such as severe acute respiratory syndrome (SARS), Flu, and Ebola infection illness, pose a major risk to human health
To affirm that the GFET biosensor was perfectly designed, definite characterization was performed after each progression
Image of rGO sheets as seen through a scanning electron microscope shown in Fig. 5(a). rGO sheets which are having less layers have been stacked and attempted to limit the wrinkles and foldings by utilizing transmission microscope (TEM)
Summary
Emerging contagious diseases, such as severe acute respiratory syndrome (SARS), Flu, and Ebola infection illness, pose a major risk to human health. In December 2019, a series of patients were admitted to the hospital with symptoms of pneumonia and severe acute respiratory syndrome (SARS) in a place named Wuhan, China The causes for this disease were unknown initially. NCov) was perceived inside the patient’s nasal liquid It was named again as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [1, 2]. World Health Organization (WHO) alluded to this infection as Corona Virus Disease (Covid-19) It declared that the virus causes this disease as a 2019 novel coronavirus (2019-nCoV). The severe symptoms of this disease may contain chest pain or pressure, shortness of breath or difficulty in breathing, and loss of speech or movement This novel coronavirus is transmitted by droplets and aerosols of human saliva. The severity of this pandemic can be observed by the statistics provided by WHO
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