Design and Development of Brahmi Extract Loaded Nanofibers for Cognitive Disorder and Its Optimization

Abstract

Cognitive disorders (CDs), also known as neurocognitive disorders (NCDs) are a category of mental health disorders that primarily affect cognitive abilities including learning, memory, perception, and problem solving. Global population with depression ranges mostly between 2% and 6% around the world today. Mental health disorders are also attributed to significant number of indirect deaths through suicide and self-harm. The aim of designing a drug delivery system is to enable drug release at a controlled rate over a desired period. nanofibers, with their large specific surface areas, can improve the solubility and dissolution rates of drugs, thereby resulting in fast release of poorly soluble active drugs. Drug release from nanofibers in terms of processing setup and modulate the release kinetics, to achieve site of action with increased plasma half life and resulting increasing residence time of drug in plasma, slowing down rapid renal clearance and helping extended presence of drug at the site of action and also minimize the toxicity of drug. Bacopa monniera an Ayurvedic drug which is mainly used for health practices. Polyvinylpyrrolidone as synthetic polymer was preferably used as a carrier for preparation of nanofibers. Nanofibers mainly prepared by using synthetic polymer because it does not have any toxic effect. Pre-formulation studies were carried out. Experimental design based on trial and error base. Total three batches were prepared using chitosan, cellulose acetate and Polyvinylpyrrolidone.FT-IR Spectroscopy study showed that there was no interaction between drug and polymer. Nanofibers were prepared by using electrospinning method. After preparation of nanofibers were subjected to various evolution parameters includes practical yield, in-vitro drug release, drug entrapment efficiency, SEM,XRD, Zeta Potential, FTIR. The formulations were optimized with respect to In-Vitro drug release and drug entrapment efficiency. Among the all formulations, the Brahmi Extract loaded PVP nanofibers batch F1 containing 300mg of brahmi extract and 600 mg polymer was optimized because this batch showed 97.57% drug release,99.24% drug entrapment efficiency,-26.4mV Zeta potential of the optimized batch which is mainly used to check the stability of the nanofibers formulation. An optimized formulation brahmi extract loaded nanofibers batch F1 is well acceptable, pleasant, palatable and with better compliance.