Abstract
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. In addition, biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. Herein, we present the a Zn(II) bioMOF based on vitamin C as an independent ligand (bioNICS-1) forming a three-dimensional chiral framework with permanent microporosity. Comprehensive study of structure stability in biorelavant media in static and dynamic conditions demonstrates relatively high structure resistivity, retaining a high degree of its parent specific surface area. Robustness of the 3D framework enables a slow degradation process, resulting in controllable release of bioactive components, as confirmed by kinetic studies. BioNICS-1 can thus be considered as a suitable candidate for the design of a small drug molecule delivery system, which was demonstrated by successful loading and release of urea—a model drug for topical application—within and from the MOF pores.
Highlights
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible Metal-organic frameworks (MOFs) with permanent porosity are still a rarity in the field
Ethanol acts as a weak ligand and has low tendency to coordinatively participate in the formation of framework structure
Such coordination diversity of Zn(II) cation within one framework structure is a rarity among MOFs and is a consequence of the multi-dentate property of ascorbic acid being fully deprotonated with all four hydroxyl and additional carbonyl O atom participating in coordination with Zn(II) centres (Supplementary Fig. 6)
Summary
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. Biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. 1234567890():,; Metal-organic frameworks (MOFs) are crystalline and generally porous materials consisting of metal ions coordinated to organic molecules, capable of forming 2D and 3D structures with specific structural features. The compositional variety of these materials allows us to create systems with an agreeable toxicological profile for the use of drug delivery, contrast agents and theranostics[6,7,8,9,10]. Such MOFs are, if constructed from at least one biologically active unit, further on referred to as bioMOFs11–13. Zn can present a suitable candidate in constructing bioMOF systems
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