Design and Control of Synthetic Biological Systems

Abstract

AbstractIn the field of synthetic biology, genetic networks are designed by combining well-characterized genetic parts, similar to electronic circuits. Such gene networks are called synthetic genetic circuits. The design approach for synthetic genetic circuits is based on mathematical modeling and numerical simulation. The approach allows the realization of various cellular functions. However, unavoidable differences in the initial states or fluctuations of the gene expression in cells have prevented the precise prediction and control of cellular behavior. Therefore, the design of synthetic genetic circuits is not sufficient, and the dynamic control of the circuits is also required. In this report, we provide examples of synthetic circuit designs and the control of synthetic biological systems, as well as perspectives on design and control.KeywordsSynthetic biologyControl engineeringSynthetic genetic circuits